A computer-supported learning platform for pupils with cognitive disabilities

Although there is no doubt that computers are highly capable to provide pupils with cognitive disabilities in learning we observe an immense lack of professional learning software for this target group. On the one hand, there are products designed by special education teachers with a high level of instructional design. But these products are usually at a low technical level, unflexible and adapted for the special situation they are designed for. On the other hand there are loads of colourful animated commercial products, but with absence of any instructional quality. In our project we want to overcome these problems by developing a learning platform for this special target group in an interdisciplinary group based on participatory design principles

Virtual Campus – Trends and Perspectives in Germany

In the last few years in Germany virtual campus initiatives have been funded considerably. In our paper we will give a review of comments and recommendations of the advisory boards in higher education policy and of the various funding schemes on the level of the federal states and the federal government. An analysis of the current program „New Media in Education” indicates trends of possible developments as well as hindrances in the virtualization of higher educationIn: A.J. Kallenberg and M.J.J.M. van de Ven (Eds), 2002, The New Educational Benefits of ICT in Higher Education: Proceedings. Rotterdam: Erasmus Plus BV, OECR ISBN 90-9016127-

Stereo-selective swelling of imprinted cholesteric networks

Molecular chirality, and the chiral symmetry breaking of resulting macroscopic phases, can be topologically imprinted and manipulated by crosslinking and swelling of polymer networks. We present a new experimental approach to stereo-specific separation of chiral isomers by using a cholesteric elastomer in which a helical director distribution has been topological imprinted by crosslinking. This makes the material unusual in that is has a strong phase chirality, but no molecular chirality at all; we study the nature and parameters controlling the twist-untwist transition. Adding a racemic mixture to the imprinted network results in selective swelling by only the component of ``correct'' handedness. We investigate the capacity of demixing in a racemic environment, which depends on network parameters and the underlying nematic order

Untwisting of a cholesteric elastomer by a mechanical field

A mechanical strain field applied to a monodomain cholesteric elastomer will unwind the helical director distribution. There is an analogy with the classical problem of an electric field applied to a cholesteric liquid crystal, but with important differences. Frank elasticity is of minor importance unless the gel is very weak. The interplay is between director anchoring to the rubber elastic matrix and the external mechanical field. Stretching perpendicular to the helix axis induces the uniform unwound state via the elimination of sharp, pinned twist walls above a critical strain. Unwinding through conical director states occurs when the elastomer is stretched along the helical axis.Comment: 4 pages, RevTeX 3 style, 3 EPS figure

Soft elasticity in biaxial smectic and smectic-C elastomers

Ideal (monodomain) smectic-$A$ elastomers crosslinked in the smectic-$A$ phase are simply uniaxial rubbers, provided deformations are small. From these materials smectic-$C$ elastomers are produced by a cooling through the smectic-$A$ to smectic-$C$ phase transition. At least in principle, biaxial smectic elastomers could also be produced via cooling from the smectic-$A$ to a biaxial smectic phase. These phase transitions, respectively from $D_{\infty h}$ to $C_{2h}$ and from $D_{\infty h}$ to $D_{2h}$ symmetry, spontaneously break the rotational symmetry in the smectic planes. We study the above transitions and the elasticity of the smectic-$C$ and biaxial phases in three different but related models: Landau-like phenomenological models as functions of the Cauchy--Saint-Laurent strain tensor for both the biaxial and the smectic-$C$ phases and a detailed model, including contributions from the elastic network, smectic layer compression, and smectic-$C$ tilt for the smectic-$C$ phase as a function of both strain and the $c$-director. We show that the emergent phases exhibit soft elasticity characterized by the vanishing of certain elastic moduli. We analyze in some detail the role of spontaneous symmetry breaking as the origin of soft elasticity and we discuss different manifestations of softness like the absence of restoring forces under certain shears and extensional strains.Comment: 26 pages, 6 figure

Electro-Mechanical Fredericks Effects in Nematic Gels

The solid nematic equivalent of the Fredericks transition is found to depend on a critical field rather than a critical voltage as in the classical case. This arises because director anchoring is principally to the solid rubbery matrix of the nematic gel rather than to the sample surfaces. Moreover, above the threshold field, we find a competition between quartic (soft) and conventional harmonic elasticity which dictates the director response. By including a small degree of initial director misorientation, the calculated field variation of optical anisotropy agrees well with the conoscopy measurements of Chang et al (Phys.Rev.E56, 595, 1997) of the electro-optical response of nematic gels.Comment: Latex (revtex style), 5 EPS figures, submitted to PRE, corrections to discussion of fig.3, cosmetic change

Symmetries and Elasticity of Nematic Gels

A nematic liquid-crystal gel is a macroscopically homogeneous elastic medium with the rotational symmetry of a nematic liquid crystal. In this paper, we develop a general approach to the study of these gels that incorporates all underlying symmetries. After reviewing traditional elasticity and clarifying the role of broken rotational symmetries in both the reference space of points in the undistorted medium and the target space into which these points are mapped, we explore the unusual properties of nematic gels from a number of perspectives. We show how symmetries of nematic gels formed via spontaneous symmetry breaking from an isotropic gel enforce soft elastic response characterized by the vanishing of a shear modulus and the vanishing of stress up to a critical value of strain along certain directions. We also study the phase transition from isotropic to nematic gels. In addition to being fully consistent with approaches to nematic gels based on rubber elasticity, our description has the important advantages of being independent of a microscopic model, of emphasizing and clarifying the role of broken symmetries in determining elastic response, and of permitting easy incorporation of spatial variations, thermal fluctuations, and gel heterogeneity, thereby allowing a full statistical-mechanical treatment of these novel materials.Comment: 21 pages, 4 eps figure

Tuning the cross-linking density and cross-linker in core cross-linked polymeric micelles and its effects on the particle stability in human blood plasma and mice

Core cross-linked polymeric micelles (CCPMs) are designed to improve the therapeutic profile of hydrophobic drugs, reduce or completely avoid protein corona formation, and offer prolonged circulation times, a prerequisite for passive or active targeting. In this study, we tuned the CCPM stability by using bifunctional or trifunctional cross-linkers and varying the cross-linkable polymer block length. For CCPMs, amphiphilic thiol-reactive polypept(o)ides of polysarcosine-block-poly(S-ethylsulfonyl-l-cysteine) [pSar-b-pCys(SO2Et)] were employed. While the pCys(SO2Et) chain lengths varied from Xn = 17 to 30, bivalent (derivatives of dihydrolipoic acid) and trivalent (sarcosine/cysteine pentapeptide) cross-linkers have been applied. Asymmetrical flow field-flow fraction (AF4) displayed the absence of aggregates in human plasma, yet for non-cross-linked PM and CCPMs cross-linked with dihydrolipoic acid at [pCys(SO2Et)]17, increasing the cross-linking density or the pCys(SO2Et) chain lengths led to stable CCPMs. Interestingly, circulation time and biodistribution in mice of non-cross-linked and bivalently cross-linked CCPMs are comparable, while the trivalent peptide cross-linkers enhance the circulation half-life from 11 to 19 h.Biopharmaceutic

Learning from multimedia and hypermedia

Computer-based multimedia and hypermedia resources (e.g., the world wide web) have become one of the primary sources of academic information for a majority of pupils and students. In line with this expansion in the field of education, the scientific study of learning from multimedia and hypermedia has become a very active field of research. In this chapter we provide a short overview with regard to research on learning with multimedia and hypermedia. In two review sections, we describe the educational benefits of multiple representations and of learner control, as these are the two defining characteristics of hypermedia. In a third review section we describe recent scientific trends in the field of multimedia/hypermedia learning. In all three review sections we will point to relevant European work on multimedia/hypermedia carried out within the last 5 years, and often carried out within the Kaleidoscope Network of Excellence. According to the interdisciplinary nature of the field this work might come not only from psychology, but also from technology or pedagogy. Comparing the different research activities on multimedia and hypermedia that have dominated the international scientific discourse in the last decade reveals some important differences. Most important, a gap seems to exist between researchers mainly interested in a “serious” educational use of multimedia/ hypermedia and researchers mainly interested in “serious” experimental research on learning with multimedia/hypermedia. Recent discussions about the pros and cons of “design-based research” or “use-inspired basic research” can be seen as a direct consequence of an increasing awareness of the tensions within these two different cultures of research on education